However, while mania or illness severity of BD showed a trend towards improvement from baseline to 12 weeks, only 16% of the sample met the criteria for the remission of symptoms of depression. 82 Another IPSRT study was conducted over a longer duration with 2-hour weekly sessions for 1 year; the researchers found that the participants who underwent the sessions experienced significant decreases in depressive symptoms and exhibited normalisation of social rhythms during the treatment duration. 82 However, no significant improvement in manic symptoms was observed.
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Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review.
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