Impact of HSD17B13 rs72613567 genotype on hepatic decompensation and mortality in patients with portal hypertension.

Liver Int · 2020 · PMC7003973 · PMID 31967400

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

showed a trendP = .067so close (0.05 < p ≤ 0.1)

Patients harbouring at least one TA ‐allele had a lower MELD (9 (8‐12) vs 10 (8‐13) points; P = .003) and showed a trend towards lower HVPG (16 ± 6 vs 17 ± 7 mmHg; P = .067).

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a numerical trendno p-value reported

Among males, there was a numerical trend towards lower serum testosterone levels in patients harbouring a TA allele, which did not attain statistical significance ( TA/TA : 3.75 ± 2.03 vs T/TA : 4.95 ± 3.62 vs T/T : 5.65 ± 3.02; P = .339; Figure S4). 4 DISCUSSION Recently, a study linking exome sequence data from the DiscovEHR cohort 13 to electronic health records reported, that the HSD17B13 rs72613567 T > TA variant is associated with reduced risks of ALD/NAFLD as well as alcoholic and non‐alcoholic cirrhosis.

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