APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.

Nat Commun · 2020 · PMC7005822 · PMID 32034147

Europe PMC DOI

hedged sentence

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significancep = 0.076so close (0.05 < p ≤ 0.1)

The GL261-APOBEC3B ACTIVE /anti-PD1 vaccine doubled median survival, although when controlling for multiple comparisons this did not reach statistical significance compared to untreated controls ( p = 0.076 Log-Rank test with Holm–Bonferroni correction for multiple comparisons).

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