In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis.

Proc Natl Acad Sci U S A · 2020 · PMC7007532 · PMID 31964806

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did not reach statistical significanceno p-value reported

Basal concentration of insulin secreted by human β-cells exhibited tendency for oscillations that did not reach statistical significance to qualify as circadian according to JTK_Cycle when applied to the time window 0 to 48 h ( Fig. 3 B ).

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