Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.

Of note, periodic acid-Schiff (PAS) staining indicated that the melatonin-treated control group displayed drastically increased goblet cells in colons, whereas TLR4 KO mice showed a trend toward decreased goblet cells compared to WT mice (Fig. 1e,f,i,j ).

also in 53,322 other papers

qRT-PCR showed significantly increased expression of Mtnr1a and an increasing trend of Mtnr1b in colons of melatonin-administered mice compared to vehicle-treated groups when also treated with DSS (Fig. 2c ).

also in 63,971 other papers

While the difference was not significant, melatonin-treated groups showed a decreasing trend in Bacteroidetes and an increasing trend of Firmicutes relative abundance compared to vehicle-treated groups (Fig. 3c ) as previous studies 17 , 28 .

also in 47,180 other papers