Wide QRS complex and the risk of major arrhythmic events in Brugada syndrome patients: A systematic review and meta-analysis.

5 Smits et al found that BrS patients with the SCN5A mutation showed a trend toward longer QRS duration in lead V2, with prolongation of both atrio‐His and His‐Ventricular (HV) interval, compared with the BrS patients without SCN5A mutation. 62 In addition, Bordachar et al also revealed that patients with an HV interval >55 milliseconds had significantly more atrial arrhythmias than those with a normal HV interval, which subsequently predispose such patients to MAE.

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