Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects.

Although only 8/18 subjects achieved a 12-month follow-up, the overall mean seizure frequency showed a decreasing trend over time, of different entity according to seizure types: indeed, frequency reduction was more pronounced for tonic-clonic seizures (−91.4%), infantile spasms (IS) (−87.5%) and atonic seizures (−86.5%) compared with focal ones; moreover, responder rate at 3 months was higher for IS and atonic seizures (75% each).

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However, seizure freedom from drop seizures during the maintenance phase appeared more likely in patients on CBD 20 mg/kg/die (Risk Ratio 6.59), although it did not reach statistical significance.

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