Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss.

We also identified other genes involved in the auditory synapse function that showed a trend towards lower expression albeit not significant in the RNAseq analysis: the inner hair cells glutamate transporter ( Slc17a8 ), glutamate ionotropic receptor AMPA type subunit 2 (Gria2) and Adenosine A1 receptor ( Adora1 ) (data not shown). qPCR results confirmed the significantly lower expression of ryanodine receptor 1, 2, 3, otoferlin, Slc17a6 , Slc17a8 and Gria2 ( Fig. 6 C).

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