Role of Baseline and Post-Therapy 18F-FDG PET in the Prognostic Stratification of Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients Treated with Radium-223.

In agreement with this finding, the imaging index virtually preserved its capability to predict the response to treatment in patients with the highest increase in PSA after Ra223 administration, as suggested by the almost significant p value ( p = 0.1 in each subgroup, see also Figure 4 ) and the emblematic example reported in Figure 5 . 4.

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PERCIST scores significantly predicted OS ( Figure 3 , p < 0.05), while this prognostic penetrance did not reach statistical significance for EORTC, deltaMTV, and deltaTLG evaluations.

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