Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease.

In contrast, BPF99 had a highly significant effect on JNK and p38 MAPK phosphorylation returning them to levels seen in chow fed mice and lower than the levels seen in positive controls (Fig. 5 , panels A, D and E; p < 0.001 for both).

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It significantly improved NASH resolution (p < 0.001) and the SAF scores (p < 0.05) while the NAS improvement approached significance.

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