A total of six studies assessed radiographic structural progression, of which five found a significant association between longer diagnosis delay and greater radiographic progression [ 6 , 46 , 50 , 59 , 61 ]; in the remaining study, there was a trend toward greater radiographic progression in patients with longer diagnosis delay, but this difference did not reach statistical significance [ 65 ] (Table 3 ).
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Clinical, Economic, and Humanistic Burden Associated With Delayed Diagnosis of Axial Spondyloarthritis: A Systematic Review.
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