Na⁺/K⁺-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.

Although adding ouabain to the bathing medium of α2 +/KOE4 brain slices further lowered (4.7%) the threshold [K + ] ACSF and further reduced the SD latency by 12.7% in α2 +/KOE4 compared to WT, these effects were considerably smaller compared to the effect of ouabain in WT slices and did not reach statistical significance ( Figure 1(d) and (e) ).

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