1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis.

J Korean Med Sci · 2020 · PMC7025907 · PMID 32056400

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0.0630

closest p · 1.3× alpha

0.0630

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did not reach statistical significanceP = 0.063so close (0.05 < p ≤ 0.1)

When CD4 + T cells obtained from healthy donors were differentiated into Th17 in the presence of various concentrations of tocilizumab and 1,25(OH) 2 D 3 , we observed that the CD4 + IL-17 + population tended to be suppressed by a combination of tocilizumab and 1,25(OH) 2 D 3, although it did not reach statistical significance ( P = 0.063) ( Fig. 1A ).

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