Targeted exome sequencing identifies five novel loci at genome-wide significance for modulating antidepressant response in patients with major depressive disorder.

Furthermore, out of the suggested loci found to be promising candidates for the antidepressant response in clinical applications after validation 34 , multiple SNPs at ABCB1, BDNF, CYP2C19, SLC6A2, CYP2D6 , and HTR2A showed a trend for influencing antidepressant response at a nominal significance in our study ( P < 0.05) (Table S17 ).

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