Neonatal Alcohol Exposure in Mice Induces Select Differentiation- and Apoptosis-Related Chromatin Changes Both Independent of and Dependent on Sex.

Front Genet · 2020 · PMC7026456 · PMID 32117449

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0.0980

closest p · 2.0× alpha

0.0980

boldest claim

The sentences

trend toward significancep = 0.098so close (0.05 < p ≤ 0.1)

We selected the lymphotoxin-beta receptor ( Ltbr ) gene for RT-qPCR follow-up due to its trend toward significance in both brain regions (cortex FC = 1.60 and p = 0.098; cerebellum FC = 1.23 and p = 0.017).

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a slight trendno p-value reported

The larger increase in DNA methylation in the cerebellum of females may correlate with a slight trend toward decreased Kdm4a expression in the ethanol-exposed group, though this will require replication with a larger sample size.

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did not reach statistical significanceno p-value reported

While this trend was in the same direction as observed for the qPCR array ( Table S6 ), ethanol-induced changes to Kmt5a did not reach statistical significance with this full set of samples, which suggested that only some animals were affected.

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