The Immunomodulatory Properties of the Human Amnion-Derived Mesenchymal Stromal/Stem Cells Are Induced by INF-γ Produced by Activated Lymphomonocytes and Are Mediated by Cell-To-Cell Contact and Soluble Factors.

Front Immunol · 2020 · PMC7028706 · PMID 32117234

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did not reach statistical significanceno p-value reported

Concerning TNF-α, both TLR agonists induced a reduction of this pro-inflammatory cytokine, even if it did not reach statistical significance.

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highly significantno p-value reported

Interestingly, we found a highly significant production of some chemokines involved in the innate immunity cell chemotaxis (IP-10, MIG, MIP-1α, and MIP-1β) in hAMSC/activated PBMC co-culture.

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