Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.

In line with our findings, intratumoral M2 macrophage levels as well as myeloid cell infiltrate levels (monocytes, M0, M1, and M2 macrophages) showed a trend toward elevated levels in NR glioblastoma patients before anti-PD-1 therapy (Fig. 5e ), supporting the hypothesis that suppressive myeloid cell subsets impair the induction of antitumor T cell responses by ICB therapy.

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