highly significantp < 0.0001
Despite the small sample sizes, these combined SNV–CNV subsets demonstrated a highly significant difference in PFS ( p < 0.0001, Fig. 3 ).
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A model combining clinical and genomic factors to predict response to PD-1/PD-L1 blockade in advanced urothelial carcinoma.
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0.0001
0.0410
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showed a trendp = 0.041
The number of estimated C>T_CpG mutations and estimated APOBEC-related mutations were both significantly higher in mUC patients with CB to ICI, whereas the number of estimated ERCC2 mutations showed a trend to be higher in mUC with CB to ICI ( p = 0.041, 0.003 and 0.078, respectively, Mann–Whitney U test, Fig. 1b–d ).