Results: Among different cancer types, we observed highly significant overlap of genes enriched in CD8-Low tumors, which included known immunomodulatory genes (e.g., BMP7, CMTM4, KDM5B, RCOR2) and exhibited significant associations with Wnt signaling, neurogenesis, cell-cell junctions, lipid biosynthesis, epidermal development, and cancer-testis antigens.
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Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types.
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The C2 signature also showed consistent expression differences between patient response groups (CR/PR, SD, PD) in both Ipi Naïve and Ipi Prog cohorts ( Figure 7C ), as well as significant and near-significant associations with patient overall survival in Ipi Naïve (pre-treatment) and Ipi Prog (pre- and on-treatment) cohorts, despite small patient numbers ( Figure 7D ).