Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4⁺ Memory Than in CD4⁺ Naïve T Cells.

When selecting an equal number of CpGs randomly among our tested sites, we generally observed a lower number of overlapping RA SNPs, however, the association between DMPs and RA risk loci did not reach statistical significance ( P = 0.1 after 1000 permutations).

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