Interleukin 1 receptor antagonist (<i>IL1RN</i>) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.

Ann Rheum Dis · 2020 · PMC7034355 · PMID 31852669

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showed a trendno p-value reported

36 What might be the biological explanation for the ‘ yin/yang’ genetic effects of CTA versus TTG on rOA? We have previously shown that individuals carrying the IL1RN CTA (TTG-0) haplotype had significantly lower synovial fluid levels of IL-10 and showed a trend towards lower levels of IL-1β and IL-6. 13 We here report that in patients with both OA and RA, carriers of the TTG haplotype exhibit reduced plasma levels of IL-1Ra compared with CTA carriers.

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did not achieve significanceno p-value reported

In the GOGO cohort, the TTG haplotype was associated with increased odds of KL 3/4 OA, which did not achieve significance.

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