12 , 13 , 25 , 36 Moreover, in the articles reporting on differences in symptom burden at different stages of the morning, there was a clear trend for the greatest impact occurring on waking, before tapering off slightly later in the morning. 13 , 25 Partridge et al. 12 reported that 37% of all the studied patients with COPD and 59% of patients with severe COPD were awoken by their symptoms in the morning at least 3 days a week.
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Daytime symptoms of chronic obstructive pulmonary disease: a systematic review.
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