Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases.

500 nM CRT0066101 for 24 hours decreased the number of cells by 45% compared to untreated cultures and increased the absolute number (not shown) and percentage of PI-positive cells from 1% in the untreated group to 5% of the 500 nM group, although this increase did not reach statistical significance. 1000 nM CRT0066101 showed stronger and statistically significant decreases in total cell number, and increases in absolute number (not shown) and percentage PI-positive cells at both timepoints.

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