Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.

Molecules · 2020 · PMC7036909 · PMID 31973227

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a clear trendno p-value reported

SAR of the phenyl group ( Table 1 ) showed a clear trend where 4-substitution was favored over 3-position, and 2-substitution was found to be detrimental for inhibitory activity (e.g., 4 , 16 and 17 ).

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