Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.

Int J Mol Sci · 2020 · PMC7037353 · PMID 32023824

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

of borderline significancep = 0.050actually significant

In ET-receptor protein expressions, some effects were detected: thecombined sitaxentan+cinacalcet slightly increased ETB protein ( p = 0.010), while the effects of sitaxentan and cinacalcet alone on ETB protein were of borderline significance ( p = 0.050 and 0.057, respectively).

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did not reach statistical significanceno p-value reported

In the 27-week model, reduced statistical power due to the loss of experimental animals may partly explain why the changes in the medulla did not reach statistical significance.

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