It should be noted that although many of the changes in 13 C- and/or 15 N- labeling of individual metabolites did not reach statistical significance, the same trend was observed for all metabolites in the same pathway pointing to the altered pathway. 3.3 miR-122 regulates expressions of Gls and Slc1a5 To understand why glutaminolysis is enhanced in miR-122 KO mice, we next determined if the expression of glutaminase is regulated by miR-122.
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