Variation of effect estimates in the analysis of mortality and length of hospital stay in patients with infections caused by bacteria-producing extended-spectrum beta-lactamases: a systematic review and meta-analysis.

98 Community acquired ESBL infections emerged in the late 1990s and show an increasing trend. 99 100 Recent study shows that community onset ESBL infections are associated with lower mortality compared with healthcare-associated and hospital-acquired infections. 101 The place of acquisition could not be appropriately addressed in our meta-analysis due to the lack of data in included studies.

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Heterogeneity of the studied effect modifiers did not reach statistical significance when assessed by metaregression ( online supplementary table S6 ).

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