A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.

Mol Brain · 2020 · PMC7045468 · PMID 32102661

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0.0507

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a strong trendp = 0.0507so close (0.05 < p ≤ 0.1)

In contrast, we observed a strong trend toward cell loss in the CA1 region of GluA2 +/ECS(G) mice compared to WT littermates at 8-10 weeks (Fig. 4 b; mean ± SD, t = 2.3, df = 8, p = 0.0507 (unpaired t-test)).

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