Impact of Single Combination Inhaler versus Multiple Inhalers to Deliver the Same Medications for Patients with Asthma or COPD: A Systematic Literature Review.

23 In a second study conducted in the US (n=2426), single-inhaler users (FP/SAL) experienced fewer acute respiratory exacerbations (AREs) than multiple-inhaler users (BDP + SAL); however, the difference did not reach statistical significance (OR=0.67; 95% CI: 0.44, 1.01; P =0.055). 21 When considering only patients with an ARE in the previous 6 months, those who received the single inhaler in the post-index period had an approximately 47% lower likelihood of a subsequent ARE (OR=0.527; 95% CI: 0.291, 0.954; P =0.034). 21 In a Canadian

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