Cigarette smoking increases the risk of nasopharyngeal carcinoma through the elevated level of IgA antibody against Epstein-Barr virus capsid antigen: A mediation analysis.

While a significant trend was observed when age at smoking initiation was evaluated overall (p‐trend < 0.01 overall), no trend remained among ever smokers ( P = .17 among ever smokers) indicating that the significant trend observed overall was due to differences between never and ever smokers and that there was no evidence for a trend with decreasing age at smoking initiation among smokers.

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After full adjustment, current smokers had a significant 1.60‐fold (95% CI = 1.30‐1.97) and former smokers a borderline significant 1.27‐fold (95% CI = 1.00‐1.60) increased NPC risk compared to never smokers.

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