Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.

Genes Dev · 2020 · PMC7050483 · PMID 32001510

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Specifically, ∼20 out of 76 documented NRF2 target genes ( Hayes and Dinkova-Kostova 2014 ) showed a trend to up-regulation in APAP-treated mice ( Fig. 7 H), and TSA suppressed the majority of these, including Cbr1 , Ptgr1 , Nqo1 , Gsta1 , Gpx4 , Srxn1 , and Hmox1 .

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