High-Dose Vitamin D-Mediated Hypercalcemia as a Potential Risk Factor in Central Nervous System Demyelinating Disease.

Front Immunol · 2020 · PMC7053380 · PMID 32161591

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A 52 weeks safety study with escalating doses of vitamin D up to 40,000 IU/day reached a mean peak serum 25(OH)D 3 level of 413 nmol/L and showed a trend toward reduced relapse rate ( 41 ).

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