A human-like bile acid pool induced by deletion of hepatic <i>Cyp2c70</i> modulates effects of FXR activation in mice.

In line with reduced amounts of CYP7A1 protein, fecal BA excretion, reflecting hepatic BA synthesis, tended to be lower in chow-fed Cyp2c70 ako mice, but this difference did not reach statistical significance ( Fig. 6F ).

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