Under starvation conditions, only PDK4 del/del cells showed significantly more perinuclear localization of mitochondria as compared to controls but PDK4 wt/del cells also showed an increasing trend.
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Functional Consequences of PDK4 Deficiency in Doberman Pinscher Fibroblasts.
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The sentences
When quantified, the results showed that while all genotypes showed a trend towards more P-PDH under starvation conditions, this phenomenon was significant in only the PDK4 wt/del and PDK4 del/del cells ( Fig. 4D ) .