Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy.

Although it did not reach statistical significance after adjustment for multiple comparisons, an increase in CDCA was observed in the faeces of UDCA-treated women; it is likely that levels of CDCA are higher in the terminal ileum than the faeces since it is efficiently uptaken by passive diffusion, via ASBT when conjugated, or biotransformed to LCA (reviewed by Crosignani et al .) 20 .

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Notable exceptions were that CA supplementation resulted in significantly higher CA levels in the faeces of supplemented mice than controls, which was not seen in the caecum; and the highly significant elevations of LCA with UDCA treatment found in the caecum were not present in the faeces.

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