A Systematic Review and Meta-Analysis of Depression and Protein-Energy Wasting in Kidney Disease.

In meta-analysis, CRP did not reach statistical significance ( Figure 3 b) but hsCRP levels correlated significantly with the severity of depressive symptoms ( Z = 0.28; 95% CI, 0.13–0.43) ( Figure 3 c).

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The mixed associations of CRP and hsCRP with depression did not clearly vary by study sample size, such that some small studies showed a highly significant difference 30 , 34 and some large studies showed none. 37 , 43 The differences in results were most likely driven by the heterogeneity of depression scales used to ascertain the presence of depression diagnosis or depressive affect or the way depression was defined in the study.

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