Biomaterial-based endochondral bone regeneration: a shift from traditional tissue engineering paradigms to developmentally inspired strategies.

Mater Today Bio · 2019 · PMC7061547 · PMID 32159148

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For example, poly( l -lactide-CO-D, l -lactide) scaffolds loaded with TGF-β3 and BMP-2 and implanted into a rat segmental defect model demonstrated enhanced bone regeneration compared to empty defects and showed a trend towards enhancing bone formation compared to scaffolds not containing TGF-β3 and BMP-2 [26] .

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