FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism.

Although levels of HDL ( Figure 4 A) and triglycerides ( Figure S5 A) in serum are comparable between Fam13a −/− and Fam13a +/+ mice, expression of the apolipoprotein A-I (Apoa1) gene that encodes major component of HDL was significantly increased in isolated hepatocytes ( Figure 4 B) and showed a trend toward increased levels in liver samples ( Figure S5 B) from Fam13a −/− mice compared with Fam13a +/+ littermates.

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