Metformin decreases hyaluronan synthesis by vascular smooth muscle cells.

J Investig Med · 2020 · PMC7063400 · PMID 31672719

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a clear trendno p-value reported

Furthermore, a clear trend of dose-dependent reduction in the amount of UDP-GlcUA in VSMCs was evident in response to metformin exposure.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.