Clinical practice guidelines for laboratory diagnosis of epidermolysis bullosa.

62 , 77 Of note, the only prospective study, which used genetic testing as an independent standard criterion to measure the diagnostic accuracy of each test, reported that IFM is more sensitive and specific than TEM, although the difference did not reach statistical significance due to an insufficient number of samples evaluated. 77 ✓ If genetic testing identifies VUS, or no pathogenic variants in EB‐associated genes are found, alterations in the immunostaining pattern and intensity may provide valuable information on the affected protein. 80 , 81 Moreover, in such situa

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