Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.

As the minor population of as few as 5% ( Dudman and Gerfen, 2015 ; Kemp and Powell, 1971 ), it is unsurprising that the interneuron overlap is borderline significant and insignificant in Mecp2 cKO vs.

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Only the Mecp2 cKO mice developed motor incoordination ( Figure 1L ) and showed a trend for increased sensorimotor gating ( Figure 1—figure supplement 2O ).

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