Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation.

In contrast, we found that the higher abundance of the 4R tau isoform selectively increased tau phosphorylation in 3-month-old hTau mice, although the associated increases in phosphorylated: total tau ratios failed to reach statistical significance.

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