IDO and Kynurenine Metabolites in Peripheral and CNS Disorders.

Front Immunol · 2020 · PMC7066259 · PMID 32194572

Europe PMC DOI

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a clear trendno p-value reported

Particularly intriguing is the finding that soluble Human Leucocyte Antigen-G (sHLA-G) levels in the serum of patients show a clear trend of correlation with symptom severity, and a statistically significant effect in the most severely affected patients ( 100 ).

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highly significantno p-value reported

There was a close and highly significant correlation between levels of kynurenine and IL-6, supporting the view that an inflammatory response had been initiated within the CNS.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.