Docosahexaenoate-enriched fish oil and medium chain triglycerides shape the feline plasma lipidome and synergistically decrease circulating gut microbiome-derived putrefactive postbiotics.

There were weakly significant decreases from baseline of glycerophosphocholine for both the FO (log 2 FC -0.12 ± 0.05; P = 0.02) and FO+MCT (log 2 FC -0.18 ± 0.07; P = 0.02) groups.

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There was a highly significant and broad effect of dietary oil inclusion on individual sphingolipids and ceramides relative to the CON group, with 83% (44/53) of observed changes from baseline significantly affected by diet (ANOVA median P < 0.001; Fig 6 ).

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