Engineered immunogen binding to alum adjuvant enhances humoral immunity.

Nat Med · 2020 · PMC7069805 · PMID 32066977

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a clear trendno p-value reported

Immunization of BALB/c mice with Ser 4 -eOD:alum or pSer-eOD:alum revealed a clear trend of increasing serum immunoglobulin (Ig)G titers as the number of phosphoserines in the affinity tag increased; pSer 8 -eOD elicited 48-fold higher serum IgG titers compared to the Ser 4 -eOD antigen, which persisted over 6 weeks (Fig. 2a,b ).

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