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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nat Commun · 2020 · PMC7070004 · PMID 32170138

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Detergent-insoluble tau levels were also increased in 3D naïve hNPCs co-cultured with I45F mutant cells even though they did not reach statistical significance (Fig. 6c, e ).

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