Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.

[ 157 ] identified 13 randomized controlled trials with a total of 39,005 adult participants and observed that folic acid supplementation did not reach statistical significance in reducing the risk of stroke (RR = 0.93; 95% CI, 0.85–1.03; p = 0.16).

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[ 163 ], examining 2570 elderly individuals (mean age, 73.1 ± 10.4 years) over a 6 year period found that the methionine to Hcy status was associated with dementia development and structural brain changes, suggesting that a higher methionine to Hcy ratio may be significant in decreasing the rate of brain atrophy and decreasing the risk of dementia in older adults.

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