Baseline Serum HE4 But Not Tissue HE4 Expression Predicts Response to the Levonorgestrel-Releasing Intrauterine System in Atypical Hyperplasia and Early Stage Endometrial Cancer.

Although a previous study reported levels of serum HE4 29% higher in smokers compared to non-smokers [ 30 , 33 ] in healthy patients, in the current study serum HE4 trended higher in smokers but did not reach statistical significance, probably due to only ~10% of patients in this study being smokers.

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