Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation.

There was a significant decrease in cell numbers over 24 h when treated with 3 nM BPA in the presence of LY294002 ( p < 0.001; Figure 1 E), and just short of significance for the U0126 ( p = 0.05; Figure 1 E). 3.2.

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Finally, CAV1 gene expression significantly increased in 10 nM BPA-treated BeWo cells compared to controls ( p < 0.01), whilst an increase that did not reach statistical significance was also noted in BeWo cells after 3 nM BPA treatment ( Figure 2 C).

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