Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer.

A similar grouping method was applied for Nrf2 expression status ( n = 224); however, here the association did not reach statistical significance for OS [ Figure S3(c) ; Nrf2 high versus Nrf2 low , 40 months versus 90 months, log-rank p = 0.24] and DFS [ Figure S3(d) ; Nrf2 high versus Nrf2 low ; 64 months versus 100 months, log-rank p = 0.12].

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